. 2020 Jun 4;10:9143. doi: 10.1038/s41598-020-65767-7

Table 1.

Results of statistical analysis of three tumour growth experiments.

	DDT deficiency (Buoninfante et al.)²⁸	AXL antibody (Boshuizen et al.)²⁹	SHP2 inhibition (Mainardi et al.)³⁰
Treatment groups	WT & K164R	lgG1-b12 4 mg/kg & AXL-107-MMAE 2 mg/kg	AZD6244 & Vehicle
Number of mice/group	15 & 15	6 & 6	7 & 10
Average number of measurements/mouse	18 & 21	16 & 17	8 & 6.2
α (95% CI)	1.982 (1.933, 2.031)	2.115 (1.839, 2.392)	2.433 (2.332, 2.534)
$β_{1}$ (95% CI)	0.025 (0.023, 0.028)	0.016 (0.009, 0.022)	0.017 (0.013, 0.020)
$β_{2}$ (95% CI)	−0.0096 (−0.011, −0.007)	−0.022 (−0.030, −0.014)	−0.008 (−0.012, −0.003)
σ (95% CI)	0.174 (0.158, 0.191)	0.487 (0.342, 0.691)	0.213 (0.168, 0.270)
ρ (95% CI)	0.852 (0.819, 0.880)	0.990 (0.980, 0.995)	0.969 (0.946, 0.982)

Abbreviation: CI, confidence interval.

Note: A linear model $l o g_{10} y_{i j} = α + β_{1} t_{i (j - 1)} + β_{2} x_{i} t_{i (j - 1)} + ϵ_{i j}$ with an autoregressive (AR-1) covariance matrix was used. α denotes the overall average log-volume at the time of randomization, $β_{1}$ is the linear change in log-volume across time for the reference group (WT, IgG1-b12 4 mg/kg, Vehicle), while $β_{2}$ is the difference between the linear change in log-volume across time between the reference group and a comparison group (K164R, AXL-107-MMAE 2 mg/kg, AZD6244), $ϵ_{i j} ~ N (0, σ^{2})$ and ρ is the autocorrelation between adjacent measurements.