Table 1.
DDT deficiency (Buoninfante et al.)28 | AXL antibody (Boshuizen et al.)29 | SHP2 inhibition (Mainardi et al.)30 | |
---|---|---|---|
Treatment groups | WT & K164R | lgG1-b12 4 mg/kg & AXL-107-MMAE 2 mg/kg | AZD6244 & Vehicle |
Number of mice/group | 15 & 15 | 6 & 6 | 7 & 10 |
Average number of measurements/mouse | 18 & 21 | 16 & 17 | 8 & 6.2 |
α (95% CI) | 1.982 (1.933, 2.031) | 2.115 (1.839, 2.392) | 2.433 (2.332, 2.534) |
(95% CI) | 0.025 (0.023, 0.028) | 0.016 (0.009, 0.022) | 0.017 (0.013, 0.020) |
(95% CI) | −0.0096 (−0.011, −0.007) | −0.022 (−0.030, −0.014) | −0.008 (−0.012, −0.003) |
σ (95% CI) | 0.174 (0.158, 0.191) | 0.487 (0.342, 0.691) | 0.213 (0.168, 0.270) |
ρ (95% CI) | 0.852 (0.819, 0.880) | 0.990 (0.980, 0.995) | 0.969 (0.946, 0.982) |
Abbreviation: CI, confidence interval.
Note: A linear model with an autoregressive (AR-1) covariance matrix was used. α denotes the overall average log-volume at the time of randomization, is the linear change in log-volume across time for the reference group (WT, IgG1-b12 4 mg/kg, Vehicle), while is the difference between the linear change in log-volume across time between the reference group and a comparison group (K164R, AXL-107-MMAE 2 mg/kg, AZD6244), and ρ is the autocorrelation between adjacent measurements.