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. 2020 Jun 4;11:2817. doi: 10.1038/s41467-020-16309-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — IP of endogenous AGO2 followed by immunoblot to detect KRAS in KRAS^G12C harboring (a) H358 and (b) MIA PaCa-2 cells treated with varying concentrations of ARS-1620 for three and nine hours, respectively. KRAS^G12D harboring (c) Panc 05.04 and (d) Panc 10.05 cells, respectively, treated with ARS-1620 for 24 h followed by AGO2 IP and immunoblot analysis of KRAS^G12D. For each cell line, input blots for AGO2 and RAS are shown.