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. 2020 May 27;52(5):843–853. doi: 10.1038/s12276-020-0443-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a VEGF, PlGF, sFlt-1, and IL-6 concentrations in the SF of RA patients with significant synovial hypertrophy (gray-scale US, GSUS 2 and 3) versus those with no or mild synovial hypertrophy (GSUS 0 and 1). b VEGF, PlGF, sFlt-1, and IL-6 concentrations in RA patients with increased vascularity (power-Doppler US, PDUS 1 to 3) and in those without (PDUS 0). c VEGF, PlGF, sFlt-1, and IL-6 concentrations in RA patients with active synovitis and in those without. Active synovitis was defined as GSUS ≥ 2 or PDUS ≥ 1. GSUS: gray-scale US; PDUS: power-Doppler US. Bars indicate the mean and SD. *p < 0.05, **p < 0.01 by Student’s unpaired t test.