Table 2.
Comparison of clinical features between favourable and unfavourable outcome groups –continued.
| Favourable outcome | Unfavourable outcome | Effect size | p value | |||||
|---|---|---|---|---|---|---|---|---|
| (PCPC < 3) | (3 ≤ PCPC) | |||||||
| n = 23 | n = 11 | |||||||
| Treatment option group, n (%) | 0.406 | 0.077 | ||||||
| Early-Hypo group | 3 | (13.0) | 5 | (45.5) | ||||
| Late-Hypo group | 11 | (47.8) | 5 | (45.5) | ||||
| Non-Hypo group | 9 | (39.1) | 1 | (9.1) | ||||
| Duration from 1st seizure, median (IQR), n | ||||||||
| to cooling initiation (Time1st-cooling) | 94 | (96.5–116 | 14 | 52.5 | (26–91.5) | 10 | 0.329 | 0.107 |
| to 35 degrees Celsius (Time1st-35 °C) | 97.5 | (71–117.5) | 14 | 54.5 | (29–93.5) | 10 | 0.335 | 0.101 |
| to 34 degrees Celsius (Time1st-34 °C) | 98.5 | (25–118) | 14 | 60 | (38–94.5) | 10 | 0.257 | 0.208 |
| Duration from 2nd phase, median (IQR), n | ||||||||
| to cooling initiation (Time2nd-cooling) | 9 | (5.3–12) | 11 | 10 | (6.5–13) | 5 | 0.114 | 0.650 |
| to 35 degrees Celsius (Time2nd-35 °C) | 10.5 | (7–14.8) | 11 | 11.5 | (7–16) | 5 | 0.085 | 0.733 |
| to 34 degrees Celsius (Time2nd-34 °C) | 11 | (8–17.3) | 11 | 14 | (13–18) | 5 | 0.184 | 0.461 |
| Associated events | ||||||||
| Hypotension, n (%) | 7 | (30.4) | 3 | (27.2) | 0.032 | 1.000 | ||
| Catecholamine use, n (%) | 8 | (34.8) | 9 | (81.8) | 0.440 | 0.026* | ||
| Pneumonia, n (%) | 3 | (13.0) | 4 | (36.4) | 0.270 | 0.178 | ||
| Thrombocytopenia, n (%)† | 9 | (39.1) | 9 | (81.8) | 0.440 | 0.003* | ||
| Minimal platelet x103/μL, median (IQR), n‡ | 18.2 | (12.3–24.3) | 23 | 7.1 | (4.9–12.0) | 11 | 0.455 | 0.007* |
| Minimal platelet excluding cooling period, x103/μL, median (IQR), n§ | 19.5 | (15.3–24.4) | 23 | 18.2 | (12.3–24.1) | 11 | 0.031 | 1.000 |
| Coagulation disorder, n (%) | 16 | (69.6) | 10 | (90.9) | 0.235 | 0.227 | ||
| Arrhythmia, n (%) | 0 | (0) | 0 | (0) | — | — | ||
| Hypokalaemia <3.5 mEq/L, n (%) | 15 | (65.2) | 10 | (90.9) | 0.272 | 0.214 | ||
| Dexmedetomidine use during cooling | 5 | (21.7) | 3 | (27.3) | 0.061 | 1.000 | ||
*p < 0.05, †Platelets <150 × 103/μL, ‡Minimal platelet count within 10 days after 1st seizure, §Minimal platelet count within 10 days excluding cooling period, ¶PT > 12 s, PT INR > 1.2 s, or APTT > 45 s.