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. 2020 Jun 4;11(6):422. doi: 10.1038/s41419-020-2638-2

Fig. 4. HK2 is required for long-term survival of photoreceptors.

Fig. 4

a Representative OCT images of 1- and 10-month-old cKO mice. b Quantitative analysis of retinal layers from OCT images. TRT, ONL and OSEL are significantly thinner in cKO mice as compared to WT animals. Schematic of retinal layers measured using OCT. OSEL is the region between the inner segment boundary and the apical surface of the RPE. c Representative hematoxylin and eosin stained sections of 10-month-old cKO and WT mice. d ONL nuclei counts normalized to total inner retinal area as a percent of the WT mice. e–h ERG amplitudes at indicated illuminance. e–g Scotopic and h photopic measurements. Amplitude is significantly decreased in cKO animals at 10 months of age. N = 8–16, *p < 0.05, **p < 0.01. TRT total retinal thickness, RNFL retinal nerve fiber layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL Outer Nuclear Layer, IS inner segments, OSEL outer segment equivalent length, RPE retinal pigment epithelium.