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. 2020 Jun 4;11:2816. doi: 10.1038/s41467-020-16703-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a NAD⁺ is degraded by ThsA, but not by ThsB. Data are presented as mean ± SEM for three independent experiments. b LC chromatograms of the NAD⁺ cleavage products. MS analyses of each chromatographic peak are presented in Supplementary Fig. 2. c ThsA hydrolyzes the Nam–ribosyl bond of NAD⁺. Molecular weights of NAD⁺, Nam, and ADPR are indicated in parentheses. d Kinetic parameters of NAD⁺ cleavage catalyzed by ThsA. Data are presented as mean ± SEM for four independent experiments. Source data are provided as Source Data file.