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. 2020 Jun 4;11:2816. doi: 10.1038/s41467-020-16703-w

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© The Author(s) 2020

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Fig. 4 — a Overall structure of ThsB containing a TIR domain (red) and an additional β-sheet (orange). Structures of the TIR domain exhibiting the Rossmann-like fold (b) and the additional antiparallel β-sheet (c) of ThsB. d Structural alignment of the TIR domain of ThsB (red) with Hydra vulgaris toll-receptor-related 2 (PDB ID: 4W8G; gray).