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Adipocyte inflammation is required for vascularization. Mice were fed HFD-dox for 10 weeks. (A-B) Endomucin staining reveals reduced vascularization in RIDad-BAT, gWAT, and sWAT. Scale bar, 300 μm. N = 4/group. (C) The angiogenic marker Vegfa is downregulated in RIDad-BAT, gWAT, and sWAT. N = 8–10/group. (D) Circulating VEGF is decreased in RIDad mice. N = 8–10/group.
