Fig. 3.

The proposed role of fibrillin-1 in adipose tissue metabolism and disease. Mutations in fibrillin-1 results in reduced functional microfibrils (green boxes). Presumably, this leads to elevated TGF-β signaling, altered mechanical properties, and impaired adipogenesis in adipose tissue (gray boxes). Either individually or combinations of these factors cause adipose tissue abnormalities such as lipodystrophy in MFS, MPLS, and NPS, or obesity (light orange boxes). Both situations can lead to metabolic syndrome (blue box)