Skip to main content
. 2020 May 29;11:986. doi: 10.3389/fimmu.2020.00986

Figure 4.

Figure 4

Clonal overlap between the Tcf1+ and Tcf1- repertoires. (A,B) Percent of the GP33+ Tcf1– repertoire found in the GP33+ Tcf1+ repertoire from either the same mouse or other mice in the same infection cohort for spleen/LN and lung repertoires. Clonal overlap was defined by identical CDR3b amino acid sequences found in both repertoires. (C) Clonal overlap between bulk blood repertoires at the various time points throughout the infection. (D) Clonal overlap of the top expanded clones in the Tcf1+ and Tcf1– virus-specific repertoires. The fraction of the top 10 most expanded GP33+ clones in the Tcf1+ repertoire that were shared between the top 10 most expanded GP33+ clones in the Tcf1– repertoire of either the same mouse or between two mice in the same cohort. (E) The fraction of the top 10 most expanded GP33+ clones in the Tcf1– repertoire that were found at any clonal frequency in the GP33+ Tcf1+ repertoire of either the same mouse or between two mice in the same cohort. (F) The fraction of the top 10 most expanded GP33– clones in the Tcf1– repertoire that were found at any clonal frequency in the GP33– Tcf1+ repertoire of either the same mouse or between two mice in the same cohort. *p ≤ 0.05, **p ≤ 0.05, ***p ≤ 0.005, not significant (n.s.) p > 0.05.