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. 2020 May 29;11:986. doi: 10.3389/fimmu.2020.00986

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Copyright © 2020 Yermanos, Sandu, Pedrioli, Borsa, Wagen, Oetiker, Welten, Pallmer, Reddy and Oxenius.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Minor differences between T cell repertoires from acute and chronic infection cohorts. (A) Jaccard index quantifying the clonal overlap between the repertoires of either animals within the same infection cohort (chronic vs. chronic, acute vs. acute) or across infection cohorts (chronic vs. acute). (B) Up- and down-regulation of particular V genes in chronic vs. acute GP33+ Tcf1+ repertoires. Each point represents a different TRB V gene segment. Y values >0 indicate that a given V gene is on average upregulated in the chronic GP33+ Tcf1+ repertoires relative to the acute GP33+ Tcf1+ repertoires. (C) Shannon evenness quantifying clonal expansion in the GP33+ and blood repertoires. Higher values indicate more similar levels of clonal expansion across the repertoire. not significant (n.s.) p > 0.05.