Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 29;8:393. doi: 10.3389/fcell.2020.00393

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Fischer, Hayn and Mierke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effect of matrix confinement and TSA-treatment on the invasiveness of the two breast cancer cell types. (A) Illustration of the invasion assay in collagen matrix scaffolds. (B) Invasiveness is presented as percentage of invasive cells and invasion depth for human MDA-MB-231 breast cancer cells and human MCF-7 breast cancer cells for loose (1.5 g/l) and dense collagen matrices (3.0 g/l). Note: these results are the same as the control conditions for TSA-treatment in (C). (C) Effect of TSA on the percentage of invasive cells and their invasion depth. (D) Cumulative probability as a comparative invasion histogram for MDA-MB-231 and MCF-7 on loose (left) and dense matrices (right). (E) Exemplary cell positions are presented in x–z direction for MDA-MB-231 (left) and MCF-7 cells (right) on dense matrices. **p < 0.01, ***p < 0.001 and n.s. not significant.