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. 2020 May 29;10:250. doi: 10.3389/fcimb.2020.00250

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Copyright © 2020 Wang, Zhou, Tang, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of different methylation patterns of promoter regions around the TSS in the three groups. (A) Schematic of the designated promoter regions and their methylation profiles. “0” denotes unmethylated and “1” methylated. The number of methylation peaks and the methylation profiles in (B) HCP, (C) ICP, and (D) LCP for each experimental group. 01: proximally methylated; 10: distally methylated; 11: fully methylated.