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. 2020 May 29;10:250. doi: 10.3389/fcimb.2020.00250

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Copyright © 2020 Wang, Zhou, Tang, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heatmap of differential methylation among the nine samples. F4ab: IPEC-J2 cells infected with F4ab ETEC; F4ac: IPEC-J2 cells infected with F4ac ETEC; Control: uninfected IPEC-J2 cells. (B) Distribution of DMRs. Genomic coordinates for these feature types were obtained from the UCSC pig reference genome. F4ab: DMRs between F4ab infected and uninfected cells; F4ac: DMRs between F4ac infected and uninfected cells. (C) Venn diagram showing the relationships among the differentially methylated genes identified. F4ab down/up: hypomethylated/hypermethylated genes between F4ab and uninfected cells; F4ac down/up: hypomethylated/hypermethylated genes between F4ac infected and uninfected cells.