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. 2020 Jun 4;10:9137. doi: 10.1038/s41598-020-66100-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Test sample results: (a) Differences in the functional connectivity of V1 according to eye state. Cold colors represent the brain regions showing higher connectivity with V1 in the eyes closed > eyes open contrast. Warm colors represent the brain regions showing higher connectivity with V1 in the eyes open > eyes closed contrast. The color bars represent the t value applicable to the image. (b) Contribution of each group to the significant differences. Blue colors represent the brain regions showing a correlation (positive for the contrast eyes closed > eyes open, left panel; negative for the contrast eyes open > eyes closed, right panel) with V1 in the eyes closed group. Red colors represent the brain regions showing a correlation (negative for the contrast eyes closed > eyes open, left panel; positive for the contrast eyes open > eyes closed, right panel) with V1 in the eyes open group. Purple colors represent brain areas showing a shift in the direction of the correlation with V1 according to the eye state. Numbers above slices represents the corresponding MNI coordinate in millimeters.