Fig. 4. Antibody responses against vaccine antigens for months (M) 0, 3, 20, 21, and 32 for IgG3, IgG4 and IgM.
Boxplots with median, interquartile ranges (IQR), upper whisker as the smallest between maximum × value and Q3 + 1.5*IQR, and lower whisker as the largest between minimum × value and Q1 – 1.5*IQR. The y-axis is in logarithm 10 scale. Data from months 0 and 3 were obtained from a previous study in the same individuals [7], thus a batch effect might be present. R3R (green): three doses of RTS,S/AS01E and a RTS,S/AS01E booster at month 20. R3C (red): three doses of RTS,S/AS01E and a comparator booster. C3C (blue): three doses of a comparator vaccine and a comparator booster.