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. 2020 May 29;11:804. doi: 10.3389/fphar.2020.00804

Figure 1.

Figure 1

The antidepressant-like effect of EE and PE in relation to FLX. Experimental design (A) (see the main text for a detailed description), body weight (B), the open field test (C), the sucrose preference test (D), the forced swimming test (E), and hippocampal 5-HT parameters (F). Standard housing (SH), social isolation (SI), fluoxetine (FLX), physical exercise (PE), and environmental enrichment (EE). Serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), 5-HT turnover [(5-HIAA/5-HT) × 100]. Statistical differences correspond to single, planned ANOVA comparisons. SI vs. SH: *p < 0.05, **p < 0.01. SI vs. all other treatments: +p < 0.05, ++p < 0.01.