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. 2020 May 29;8:361. doi: 10.3389/fcell.2020.00361

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Copyright © 2020 Ren, Song, Ni, Kang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The processes of mitotic cycle and endocycle. (A) The mitotic cycle comprises Gap 1 phase (G1), synthesis phase (S), Gap 2 phase (G2), and mitosis (M) phase. (B) The endocycle have two variations, endomitosis and endoreplication. Endomitosis consists of G1, S, and G2 phases and only a partial M phase. Endoreplication consists of repeated successions of S to G phase that completely skips mitosis phase. Re-replication is a special type of endoreplication, in which DNA replication is initiated multiple times at individual origin of replication within the same S phase.