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. 2020 May 29;8:361. doi: 10.3389/fcell.2020.00361

FIGURE 4.

FIGURE 4

Regulation of mitotic/endocycle switch. In the Drosophila follicle cell, Notch signaling pathway is a key upstream regulator of the mitotic/endocycle switch (MES). Activated Notch protein by the ligand Delta from oocytes terminates follicle cell proliferation and promotes MES by downregulating String (STG) and Dacapo (DAP) and upregulating FZR. In the Drosophila glial cell, Hippo signaling pathway is involved in MES. miR-285 suppresses Yki-Mask dimer activity by targeting Mask to downregulate cyclin E (CycE). Moreover, the N-terminal asparagine amidohydrolase homolog Öbek counteracts the activity of Yki and Heartless to limit endoreplication. FZR, Cdh1/Fizzy-related; Yki, Yorkie; Mask, Multiple Ankyrin repeats Single KH domain; Hnt, Hindsight; Ttk, Tramtrack; Cdk1 and 2, Cyclin-dependent kinase 1 and 2; Myt1, Myelin transcription factor 1; CycA and B, cyclin A and B; Diap1, Drosophila inhibitor-of-apoptosis protein 1; AurB, AuroraB.