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. 2020 Feb 26;318(5):E625–E635. doi: 10.1152/ajpendo.00480.2019

Fig. 4.

Fig. 4.

Signal transducer and activator of transcription 3 (Stat3) inhibition improves high-fat diet (HFD)-induced insulin resistance (IR) in mice. A and B: C56/BL6 mice were fed with HFD for 2 wk, and the representative Western blotting is shown with image quantification at bottom (A) and the Fbxo40 mRNA (B) [*P < 0.05 vs. regular diet (RD), n ≥ 4 mice]. C and D: 12 wk of HFD feeding induced obesity (C) and glucose intolerance (D) in mice (*P < 0.05 vs. RD; n ≥ 5 mice). E: TTI-101 treatment of HFD mice decreased their fasting glucose level [*P < 0.05 vs. HFD-diluent (D5W); n ≥ 7 mice]. F: TTI-101 treatment of HFD-fed mice improved their glucose tolerance (*P < 0.05 vs. HFD-D5W; n = 10 mice). G: TTI-101 treatment of HFD-fed mice improved their insulin tolerance (*P < 0.05 vs. HFD-D5W; n = 10 mice). H: the representative Western blotting is shown with image quantification at bottom (*P < 0.05 vs. RD; #P < 0.05 vs. HFD-D5W; n = 3 mice for Western). BW, body weight; GTT, glucose tolerance test; ITT, insulin tolerance test; IRS1, insulin receptor substrate 1.