Table 1.

List of model assumptions

Model Features	Assumption	Reference
LV’s geometry	Ellipsoidal	11
LV’s passive properties	Anisotropic hyperelastic and incompressible	29
LV’s active properties	Modified Hill type	30
LV’s boundary conditions	Zero mean translation and rotation	72
Left atrium	Time varying elastance model	73
Resistances and compliances of systemic circulation	Windkessel model	72
Coronary tree geometry	Anatomically realistic tree reconstructed from morphometric measurements of a swine LCX	44
Coronary vessel passive properties	Sigmoidal shape of pressure versus diameter; Tethering of vessels to myocardium	52
Outflow pressure boundary condition	Transmural depth dependent	1
Target precapillary flow rate	Constant value in all terminal order 1 vessels. Flow rate is estimated from microvascular velocity under maximum dilation	76
Transmural precapillary density	Subendocardium is higher than in the subepicardium	41

LCX, left circumflex; LV, left ventricle.