Fig. 4.
Structural damage in kidneys of AgtAgrp-KO mice [mice exhibiting selective deletion of the angiotensinogen (Agt) gene in cells that express agouti-related peptide (Agrp)]. Representative hematoxylin and eosin (H&E)-stained section of surviving 18-wk-old male kidneys (images from AgtAgrp-KO and age/cage/litter-matched brother). Note the pitted surface of the AgtAgrp-KO kidney (arrows) and thin cortex (double arrow) compared with control. Within the cortex (inset) there was substantial lymphoplasmacytic interstitial nephritis (thick arrows) and glomerulosclerosis (encircled). Bars = 500 µm (large images) and 50 µm (insets).