. 2022 Dec 30;20(11):2983–2988. doi: 10.1111/ajt.16001

TABLE 2.

Characteristics of the 4 COVID-19 patients with severe bilateral pneumonia at hospital admission treated with reparixin

	Pt1	Pt2	Pt3	Pt4
Age	63	57	62	47
Sex	M	M	M	F
Comorbidity	Diabetes	Hypertension, dyslipidemia	Hypertension, dyslipidemia, obstructive Sleep apnea	Diabetes, cardiovascular disease, mood disorder
Ongoing treatment	Insulin	Angiotensin II receptor blockers, statin	Aspirin, angiotensin II receptor blockers, statin	Insulin, aspirin, nitrate
Hospital admission
Symptoms	Fever, cough, dyspna	Fever, cough, diarrhea, anosmia, dysgeusia, dyspnoea	Fever, dyspnea	Fever, dyspnea
Time of symptoms onset^a	Day −14	Day −7	Day −10	Day-7
Oxygen saturation (SpO2)	89%; Start CPAP	89%; Start CPAP	87%; Start CPAP	84%; Start CPAP
Chest X-ray	Bilateral pneumonia	Bilateral pneumonia	Bilateral pneumonia	Bilateral pneumonia
Reparixin treatment
Time^a	Day +4	Day +3	Day +5	Day +2
Dose	IV infusion (2.772 mg/kg body weight/hour) for 5 days
PaO₂/FiO₂ ratio (mm Hg)	105	129	127	-
White blood cell, ×10⁹/L	16.2	6	7.5	10.5
Lymphocyte count, ×10⁹/L	0.9	0.6	0.6	0.8
Neutrophil count, ×10⁹/L	14.5	4.9	6.2	8.6
Platelet count, ×10⁹/L	497	390	273	491
Creatinine, mg/dL	0.77	0.97	1.89	0.53
Lactate dehydrogenase, U/L	535	472	331	513
C-reactive protein, mg/L	342.8	127.4	81.8	339.8
Serum crosslinked fibrin, μg/mL	1.99	4.31	2.07	10.56
Serum ferritin, ng/mL	1202	1467	2978	461
IL-6, pg/mL	196	—	23	—
Follow up
Status^a	Alive at day +45	Alive at day +42	Alive at day +44	Alive at day +41
Admitted to ICU^a	Yes, day +6	Yes, day +3	No	Yes, day +8
ICU discharged^a	No	No	—	No
Hospital discharged^a	No	No	Yes, day +22	No

Abbreviations: COVID-19, coronavirus disease 2019; CPAP, continuous positive airway pressure; ICU, intensive care unit.

^{^a}

All times are calculated considering the day of hospitalization as day 0.