Table 3.

Multivariable Adjustment for Confounding Factors for Progression-free Survival by Cox Proportional Hazards Regression Model Stratified by Immune-related Adverse Events

	HR for Disease Progression or Death (95% CI)	P
Standard vs. nonstandard group	2.6 (0.7-9.6)	.157
Never vs. current/former smoker	4.2 (1.6-11.3)	.004
Pembrolizumab alone vs. along with chemotherapy	2.7 (1.2-6.2)	.016
< 50% vs. ≥ 50% PD-L1 TPS	0.9 (0.4-2.1)	.873
ECOG PS ≥ 2 vs. 0-1	0.8 (0.4-1.9)	.700
No. of treatment cycles	0.7 (0.6-0.8)	<.001

Abbreviations: CI = Confidence interval; ECOG = Eastern Cooperative Oncology Group; HR = hazard ratio; PD-L1 = programmed death-ligand 1; PS = performance status; TPS = tumor proportion score.

Bold values are significant.