Supplemental Table 3.

Univariate Analysis of Overall Survival by Cox Proportional Hazards Regression Model

	HR for Death (95% CI)	P
Standard vs. nonstandard group	6.9 (2.1-22.9)	.002
Age (years)	1.0 (0.9-1.1)	.060
Never vs. current/former smoker	1.5 (0.6-4.0)	.85
ECOG PS ≥ 2 vs. 0-1	1.8 (0.8-3.9)	.175
<50% vs. ≥50% PD-L1 TPS	1.4 (0.7-2.9)	.90
Later vs. first line of therapy	0.5 (0.2-1.3)	.167
Pembrolizumab alone vs. along with chemotherapy	1.0 (0.5-2.1)	.944
No. of treatment cycles	0.8 (0.7-0.9)	<.001
Absence vs. presence of any grade irAE	2.2 (1.1-4.5)	.030
VMC vs. BIDMC	0.8 (0.4-1.7)	.615

Abbreviations: BIDMC = Beth Israel Deaconess Medical Center; CI = confidence interval; ECOG = Eastern Cooperative Oncology Group; HR = hazard ratio; irAE = immune-related adverse events; PD-L1 = programmed death-ligand 1; PS = performance status; TPS = tumor proportion score; VMC = Vidant Medical Center.

Bold values are significant.