Table 2.
Sites of GSK3α/β- and PKR-mediated phosphorylation in TAU (MAPT).
| Isoform | Phosphorylation site | Kinase |
Ref. # | ||
|---|---|---|---|---|---|
| GSK3α | GSK3β | PKR | |||
| TAU isoform 2 | S307 (S713) | X | [87] | ||
| TAU isoform 2 | S315 (S721) | X | [87] | ||
| TAU isoform 5 | T181 (T498) | X | [88] | ||
| TAU isoform 5 | S184 (S501) | X | [88] | ||
| TAU isoform 5 | S195 (S512) | X | [88] | ||
| TAU isoform 5 | S198 (S515) | X | [88] | ||
| TAU isoform 5 | S199 (S516) | X | [88] | ||
| TAU isoform 5 | S202 (S519) | X | [88] | ||
| TAU isoform 5 | T205 (T522) | X | [88] | ||
| TAU isoform 5 | T231 (T548) | X | [87,88] | ||
| TAU isoform 5 | S235 (S552) | X | [87,88] | ||
| TAU isoform 5 | S262 (S575) | X | [88] | ||
| TAU isoform 5 | S325 (S673) | X | [88] | ||
| TAU isoform 5 | S365 (S713) | X | [87] | ||
| TAU isoform 5 | S369 (S717) | X | [88] | ||
| TAU isoform 5 | S373 (S721) | X | [87,88] | ||
| TAU isoform 6 | T173 (T548) | X | [87,89] | ||
| TAU isoform 6 | S177 (S552) | X | [87] | ||
| TAU isoform 6 | S338 (S713) | X | [87,89] | ||
| TAU isoform 6 | S346 (S721) | X | [87,89] | ||
| TAU isoform 8 | S46 (S46) | X | [90] | ||
| TAU isoform 8 | T50 (T50) | X | [90] | ||
| TAU isoform 8 | T153 (T470) | X | [91] | ||
| TAU isoform 8 | T175 (T492) | X | [91] | ||
| TAU isoform 8 | T181 (T498) | X | [[92], [93], [94]] | ||
| TAU isoform 8 | S195 (S512) | X | [95] | ||
| TAU isoform 8 | S199 (S516) | X | [95,96] | ||
| TAU isoform 8 | S202 (S519) | X | [92,96] | ||
| TAU isoform 8 | T205 (T522) | X | [95,96] | ||
| TAU isoform 8 | S210 (S527) | X | [95] | ||
| TAU isoform 8 | T212 (T529) | X | [92,96] | ||
| TAU isoform 8 | S214 (S531) | X | [93,95] | ||
| TAU isoform 8 | T217 (T534) | X | [92,96] | ||
| TAU isoform 8 | T231 (T548) | X | X | [87,92,[97], [98], [99]] | |
| TAU isoform 8 | S235 (S552) | X | X | [87,91,98] | |
| TAU isoform 8 | S262 (S579) | X | X | X | [93,[96], [97], [98],101] |
| TAU isoform 8 | S356 (S673) | X | [101] | ||
| TAU isoform 8 | S396 (S713) | X | X | [87,95,96] | |
| TAU isoform 8 | S400 (S717) | X | [95,100] | ||
| TAU isoform 8 | S404 (S721) | X | X | [87,95,96] | |
| TAU isoform 8 | S409 (S726) | X | [93] | ||
| TAU isoform 8 | S422 (S739) | X | [93] | ||
Information was obtained from the PhosphoSitePlus Database under the substrate page for the following: