Table 5:
Outcomes of 186 hospitalized patients with acute respiratory illness and tested for COVID-19
| COVID-19 Positive (n=26) |
COVID-19 Negative (n=160) |
P value | |
|---|---|---|---|
| ICU admission | |||
| ICU stay during hospitalization | 11/26 (42%) | 42/160 (26%) | 0.092 |
| Time to ICU, median days (IQR) | 3.1 (0.4, 4.77) | 0.3 (0.2, 0.4) | 0.027 |
| ICU days, median days (IQR)* | 8.8 (2.7, 17.8) | 2.9 (1.6, 5.7) | 0.005 |
| Intensive care unit interventions | |||
| Endotracheal intubation | 6/11 (55%) | 21/42 (50%) | 0.788 |
| Paralytics | 2/11 (18%) | 3/42 (7%) | 0.275 |
| Prone positioning | 1/11 (9%) | 0/42 (0%) | 0.208 |
| Vasopressors | 6/11 (55%) | 21/42 (50%) | 0.788 |
| Extracorporeal membrane oxygenation | 0/11 (0%) | 0/42 (0%) | --- |
| Renal replacement therapy | 1/11 (9%) | 5/42 (12%) | 1.000 |
| Acute respiratory distress syndrome† | 6/26 (23%) | 5/160 (3%) | <0.001 |
| Acquired cardiomyopathy‡ | 1/26 (4%) | 5/160 (3%) | 1.000 |
| Troponin tested | 14/26 (54%) | 113/160 (71%) | 0.088 |
| Any troponin elevation | 5/14 (36%) | 37/113 (33%) | 0.824 |
| Acute kidney injury§ | 10/26 (39%) | 56/160 (35%) | 0.732 |
| Time to acute kidney injury, median days (IQR) | 0.07 (0.03, 4.2) | 0.08 (0.02, 1.9) | 0.343 |
| Abnormal coagulation test | |||
| Elevated INR | 4/19 (21%) | 30/107 (28%) | 0.779 |
| Elevated aPTT | 5/10 (50%) | 15/63 (24%) | 0.085 |
| Elevated d-dimer | 4/4 (100%) | 14/16 (88%) | 1.000 |
| Elevated fibrinogen | 8/9 (89%) | 12/20 (60%) | 0.201 |
| Final diagnosis | |||
| Pulmonary - infectious | 26/26 (100%) | 63/160 (39%) | <0.001 |
| Pulmonary - non-infectious | 0/26 (0%) | 27/160 (17%) | |
| Other infectious | 0/26 (0%) | 24/160 (15%) | |
| Cardiac | 0/26 (0%) | 19/160 (12%) | |
| Malignancy | 0/26 (0%) | 6/160 (4%) | |
| Renal | 0/26 (0%) | 3/160 (2%) | |
| Other | 0/26 (0%) | 18/160 (11%) | |
| Discharge disposition | 0.285 | ||
| Died | 1/26 (4%) | 15/160 (9%) | |
| Home | 13/26 (50%) | 78/160 (49%) | |
| Home hospice | 0/26 (0%) | 3/160 (2%) | |
| Home with services | 8/26 (31%) | 37/160 (23%) | |
| Skilled nursing facility | 2/26 (8%) | 25/160 (16%) | |
| Still admitted | 2/26 (8%) | 2/160 (1%) | |
| Length of stay, median days (IQR)* | 10.7 (7.9, 22.7) | 4.7 (2.9, 7.0) | <0.001 |
Legend
All outcomes assessed through April 25, 2020.
COVID-19 - Coronavirus Disease 2019; ICU - intensive care unit; INR - international normalised ratio; aPTT - activated partial thromboplastin time
*
censored at April 25; length of stay for those still admitted, calculated
†
ARDS defined using Berlin definition37
‡
based on treating physician diagnosis
§
based on KDIGO definition38