Table 1. Patient Characteristics for the SRS Cohort.
| Variable | No. (%) |
|---|---|
| No. | 710 |
| Age, median (IQR) | 68.5 (62-74) |
| Sex | |
| Men | 531 (74.8) |
| Women | 179 (25.2) |
| KPS score | |
| 90-100 | 437 (61.5) |
| 70-80 | 222 (31.3) |
| ≤60 | 51 (7.2) |
| No. of brain metastases treated | |
| Median (IQR) | 2.5 (1-6) |
| 1 | 232 (32.7) |
| 2-4 | 251 (35.4) |
| 5-10 | 137 (19.3) |
| ≥11 | 90 (12.7) |
| Brain metastasis at diagnosis | |
| No | 472 (66.5) |
| Yes | 238 (33.5) |
| Region | |
| Asia | 540 (76.1) |
| North America and Europe | 170 (23.9) |
| Extracranial metastasesa,b | |
| Absent | 328 (56.1) |
| Present | 257 (43.9) |
| Unreported | 125 |
| Extracranial disease statusa | |
| Controlled | 191 (44.5) |
| Uncontrolled | 238 (55.5) |
| Unreported | 281 |
| Leptomeningeal progression after SRS | |
| No | 379 (89.2) |
| Yes | 46 (10.8) |
| Unreported | 285 |
| Salvage WBRT after SRS | |
| No | 596 (83.9) |
| Yes | 114 (16.1) |
| Salvage SRS after upfront SRS | |
| No | 472 (66.5) |
| Yes | 238 (33.5) |
| Neurological mortality | |
| No | 567 (87.6) |
| Possible or likely | 80 (12.4) |
| Unreported | 63 |
| Vital status at reporting | |
| Alive | 114 (16.1) |
| Deceased | 596 (83.9) |
| Treatment year, median (IQR) | 2011 (2004-2014) |
Abbreviations: IQR, interquartile range; KPS, Karnofsky Performance Status; SRS, stereotactic radiosurgery; WBRT, whole-brain radiotherapy.
a
Subset analyses limited to patients with known status for extracranial metastases and extracranial disease control status are presented in the Results and eTables 7 and 8 in the Supplement.
b
As noted in the Methods section, extracranial metastases refers to extracranial disease outside of the primary thoracic tumor and regional lymph nodes.