Table 2.
Serum 25(OH)D3 levels and plasma inflammatory marker levels in colorectal cancer patients at diagnosis and several time points after diagnosis.
| n | 25(OH)D3 | n | IL10 (pg/ml) |
n | IL8 (pg/ml) | n | IL6 (pg/ml) | n | TNFα (pg/ml) | n | hsCRP**
(μg/ml) |
n | Inflammatory z-score* | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| At diagnosis | 781 | 53.9 (40.8–70.2) |
731 | 0.2 (0.2–0.4) |
769 | 5.8 (4.3–8.2) |
767 | 1.0 (0.7–1.7) |
769 | 2.1 (1.7–2.6) |
686 | 2.5 (1.1–6.0) |
643 | –0.5 (–2.3–1.8) |
| Six months after diagnosis | 641 | 50.9 (37.2–69.7) |
593 | 0.3 (0.2–0.5) |
633 | 5.1 (4.0–6.8) |
632 | 1.0 (0.7–1.8) |
636 | 2.4 (2.0–3.0) |
568 | 1.8 (0.9–4.1) |
514 | –0.5 (–2.4–1.6) |
| One year after diagnosis | 294 | 52.3 (38.6–72.3) |
226 | 0.3 (0.2–0.4) |
244 | 4.7 (3.5–6.3) |
242 | 0.9 (0.6–1.5) |
244 | 2.2 (1.7–2.8) |
185 | 1.7 (0.7–4.4) |
170 | –0.6 (–2.2–2.1) |
| Two years after diagnosis | 467 | 64.1 (49.0–82.8) |
397 | 0.2 (0.2–0.3) |
418 | 5.7 (4.4–7.2) |
404 | 0.8 (0.5–1.3) |
419 | 1.9 (1.6–2.5) |
381 | 0.0 (–1.8–1.6) |
Values were presented as median (IQR).
*
The inflammatory z-score was calculated as, where x is a participant’s cytokine value at a given visit, and µ and ơ are the study population mean and standard deviation at that visit, respectively. The combined score was calculated by summing the z-scores of each inflammatory marker.
**
hsCRP was only measured at diagnosis, 6 months and 1 year after diagnosis.