Table 3.
Association between serum 25(OH)D3 and plasma inflammatory markers at diagnosis and several time points after diagnosis.
| n | IL10 β (95% CI) |
n | IL8 β (95% CI) |
n | IL6 β (95% CI) |
n | TNFα β (95% CI) |
n | hsCRP*
β (95% CI) |
n | Inflammatory z-score**
β (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 25(OH)D3 (continuous per 10 nmol/l) | ||||||||||||
| At diagnosis | ||||||||||||
| Model 1 | 729 | −0.02 (–0.05 to 0.00) |
767 | −0.01 (–0.03 to 0.01) |
765 | −0.06 (–0.08 to –0.03) |
767 | −0.00 (–0.01 to 0.01) |
685 | −0.03 (–0.07 to 0.01) |
642 | −0.14 (–0.26 to –0.02) |
| Model 2 | 685 | −0.02 (–0.05 to 0.01) |
722 | −0.00 (–0.03 to 0.02) |
720 | −0.07 (–0.09 to –0.04) |
722 | 0.00 (–0.01 to 0.01) |
647 | −0.04 (–0.09 to 0.01) |
605 | −0.15 (–0.29 to –0.02) |
| Six months after diagnosis | ||||||||||||
| Model 1 | 587 | −0.01 (–0.04 to 0.01) |
625 | −0.00 (–0.03 to 0.01) |
624 | −0.06 (–0.08 to –0.03) |
628 | 0.00 (–0.01 to 0.02) |
560 | −0.06 (–0.10 to –0.02) |
509 | −0.16 (–0.29 to –0.04) |
| Model 2 | 549 | 0.00 (–0.03 to 0.03) |
583 | 0.00 (–0.02 to 0.02) |
581 | −0.05 (–0.07 to –0.02) |
585 | 0.01 (–0.01 to 0.02) |
523 | −0.03 (–0.08 to 0.02) |
479 | −0.09 (–0.22 to 0.05) |
| One year after diagnosis | ||||||||||||
| Model 1 | 226 | −0.00 (–0.04 to 0.04) |
244 | −0.02 (–0.06 to 0.02) |
242 | −0.03 (–0.08 to 0.02) |
244 | −0.00 (–0.03 to 0.02) |
184 | −0.05 (–0.13 to 0.02) |
170 | −0.12 (–0.33 to 0.09) |
| Model 2 | 199 | 0.00 (–0.05 to 0.06) |
212 | 0.01 (–0.04 to 0.05) |
211 | −0.06 (–0.13 to 0.00) |
212 | 0.00 (–0.03 to 0.03) |
155 | −0.05 (–0.15 to 0.05) |
146 | −0.14 (–0.41 to 0.14) |
| Two years after diagnosis | ||||||||||||
| Model 1 | 397 | −0.00 (–0.03 to 0.03) |
418 | −0.00 (–0.02 to 0.01) |
404 | −0.05 (–0.08 to –0.02) |
418 | −0.01 (–0.02 to 0.00) |
361 | −0.08 (–0.18 to 0.02) |
||
| Model 2 | 357 | 0.01 (–0.02 to 0.05) |
376 | −0.00 (–0.02 to 0.02) |
364 | −0.03 (–0.07 to 0.00) |
376 | −0.01 (–0.03 to 0.01) |
343 | −0.04 (–0.15 to 0.07) |
||
Model 1, crude model; Model 2, adjusted for cohort, season of blood collection, age, gender, use of NSAIDs, BMI, physical activity, having comorbidities and stage of disease.
To interpret the beta coefficient of the regression line, the exponential of the beta should be taken (EXP^β), since a natural log transformation was done on the outcome variable.
hsCRP was only measured at diagnosis, 6 months and 1 year after diagnosis.
The inflammatory z-score was calculated as, where x is a participant’s cytokine value at a given visit, and µ and ơ are the study population mean and standard deviation, respectively. The combined score was calculated by summing the z-scores of each inflammatory marker.