Table 5. . Surgery: outcomes and complications.
| Study (year) | OS | PFS | Median survival | Mortality | Morbidity | Ref. |
|---|---|---|---|---|---|---|
| Fourquier et al. (1997) | 5 yrs: 44% | 5 yrs; 25% | 25 | 2% | 6% | [12] |
| Robert et al. (1997) | 2 yrs: 69%; 5 yrs: 48%; 10 yrs: 35% | ns | ns | 1.8% | ns | [44] |
| Pastorino et al. (1997) | 5 yrs: 36%; 10 yrs: 26%; 15 yrs: 22% | ns | 35 | 1% | ns | [10] |
| Van der Veen et al. (1998) | 5 yrs: 38% | ns | ns | 0% | 15.3% | [13] |
| Abecasis et al. (1999) | 5 yrs: 29.2% | ns | ns | 4.7% | 21.2% | [45] |
| Kolodziejski et al. (1999) | 5 yrs: 58%; 10 yrs: 38% | ns | 58 | 2.1% | 9.6% | [35] |
| Leo et al. (2000) | 5 yrs: 22%; 10 yrs: 16% | ns | 17 | ns | ns | [46] |
| Friedel et al. (2001) | 5 yrs: 35%; 10 yrs: 20%; 15 yrs: 18% | ns | 35 | ns | ns | [47] |
| Piltz et al. (2002) | ns | ns | 61 | 0.95% | 10.7% | [48] |
| Planchard et al. (2003) | 3 yrs: 58%; 5 yrs: 45%; 10 yrs: 30% | 1 yr: 87%; 3 yrs: 48% | 50.4 (2–252) | 0.8% | ns | [49] |
| Monteiro et al. (2004) | 5 yrs: 47.4%; 10 yrs: 37.7% | 5 yrs: 33.9%; 10 yrs: 19.1% | ns | 0 | 11.5% | [36] |
| Vogelsang et al. (2004) | 1 yr: 90%; 3 yrs: 47% | ns | ns | 0% | 3% | [50] |
| Shiono et al. (2005) | 5 yrs: 61.4% | ns | ns | 0% | ns | [51] |
| Casali et al. (2006) | 5 yrs: 36% | 5 yrs: 26% | ns | ns | ns | [52] |
| Furak et al. (2006) | 5 yrs: 33.6% | ns | ns | 0 | ns | [53] |
| Harting et al. (2006) | 3 yrs: 46.2%; 5 yrs: 29% | ns | ns | ns | 11.8% | [54] |
| Rena et al. (2006) | 5 yrs: 37%; 10 yrs: 15.8% | 5 yrs: 28%; 10 yrs: 13% | ns | 0.9% | 7.9% | [55] |
| Assouad et al. (2007) | 5 yrs: 34.4% | ns | 35 | 0 | 15.4% | [15] |
| Melloni et al. (2007) | 3 yrs: 50%; 5 yrs: 42%; 10 yrs: 30% | ns | 37 | ns | ns | [16] |
| Veronesi et al. (2007) | 5 yrs: 60% | ns | ns | ns | ns | [56] |
| Dahabre et al. (2008) | 5 yrs: 32.69% | ns | 42 | 0 | 0 | [9] |
| Smith et al. (2008) | 5 yrs: 15% | 5 yrs: 5% | 16 | 3.7% | ns | [17] |
| Yoshimoto et al. (2008) | 5 yrs: 54%; 10 yrs: 40%; 20 yrs: 25% | ns | 75.6 | 1.1% | ns | [37] |
| Winter et al. (2008) | 5 yrs: 20.9% | ns | 19.4 | 4.4% | 7.4% | [57] |
| Lin et al. (2009) | 5 yrs: 43.9%; 10 yrs: 19.5% | 5 yrs: 19.5% | ns | 0% | 0% | [58] |
| Rama et al. (2009) | 3 yrs: 61%; 5 yrs: 48%; 10 yrs: 11% | ns | ns | 0% | 8% | [59] |
| Takakura et al. (2009) | 3 yrs: 64.9%; 5 yrs: 48.2% | ns | ns | ns | ns | [60] |
| Borasio et al. (2010) | 5 yrs: 55.4%; 10 yrs: 30.8% | ns | 28.8 (6–99.3) | 0 | 13.1% | [61] |
| Riquet et al. (2010) | 5 yrs: 41%; 10 yrs: 27% | ns | 45 | 0 | 14.5% | [62] |
| Sardenberg et al. (2010) | 5 yrs: 34.7% | ns | 36.7 | 0% | 9.1% | [63] |
| Tacconi et al. (2010) | 3 yrs: 57.9%; 5 yrs: 38.4% | 3 yrs: 53.5%; 5 yrs: 40.9% | ns | 0% | 2.3% | [64] |
| Casiraghi et al. (2011) | 2 yrs: 74%; 5 yrs: 46% | ns | ns | 0 | 13.8% | [65] |
| Long et al. (2011) | 3 yrs: 59.8%; 5 yrs: 47.2% | ns | 40 | 0 | 3.6% | [66] |
| Stephens et al. (2011) | ns | ns | 24.1 | ns | ns | [67] |
| Zabaleta et al. (2011) | 3 yrs: 70.2%; 5 yrs: 54.3% | ns | 72 (0–129) | 2% | 8.3% | [68] |
| Blackmon et al. (2012) | 5 yrs: 55.4% | ns | 70.1 | 0 | 1.7% | [18] |
| Chua et al. (2012) | 3 yrs: 41%; 5 yrs: 34% | 1 yr: 45%; 3 yrs: 25% | 23 | 1% | ns | [69] |
| Goonerante et al. (2012) | 5 yrs: 40% | ns | ns | 0% | 14% | [19] |
| Hirosawa et al. (2012) | 2 yrs: 76.6%; 5 yrs: 46.7% | ns | ns | 0 | ns | [70] |
| Mizuno et al. (2012) | ns | ns | 50 | ns | 7.6% | [20] |
| Lo Faso et al. (2013) | ns | ns | ns | 0 | Major 2.4% | [71] |
| Poletti et al. (2013) | 1 yr: 96%; 3 yrs: 77%; 5 yrs: 56%; 10 yrs: 39% | ns | ns | 1.9% | 22.1% | [38] |
| Cho et al. (2014) | 5 yrs: 55.6% | 5 yrs: 64.1% | ns | ns | ns | [72] |
| Renaud et al. (2014) | ns | ns | ns | 2% | ns | [73] |
| Renaud et al. (2014) | 1 yr: 88%; 2 yrs: 72%; 3 yrs: 66%; 5 yrs: 58% | ns | 94 | ns | ns | [74] |
| Zampino et al. (2014) | 5 yrs: 43% | ns | 50.4 | 0% | ns | [75] |
| Booth et al. (2015) | 5 yrs: 40%; 10 yrs: 27% | ns | ns | 0.9% | ns | [41] |
| Hou et al. (2015) | 5 yrs: VATS: 50%; Open: 46% | ns | ns | 0% | VATS: 19%; open: 23% | [21] |
| Seebacher et al. (2015) | 5 yrs: 27.9% | ns | ns | 0.3% | 5.7% | [76] |
| Guerrera et al. (2016) | 2 yrs: 80%; 5 yrs: 53% | 2 yrs: 54%; 5 yrs: 33% | ns | 0.5% | 2% | [77] |
| Filippi et al. (2016) | 1 yr: 96%; 2 yrs: 82% | ns | ns | 1 (0.7%) | 0% | [30] |
| Franzke et al. (2016) | 1 yr: 88.2%; 3 yrs: 71.4%; 5 yrs: 69.3% | ns | 51.0 (46.9–55.1) | 0 | 11.5% | [78] |
| Girelli et al. (2016) | 5 yrs: 66.8%; 10 yrs: 40.5% | ns | 90.9 | ns | ns | [79] |
| Okiror et al. (2016) | ns | ns | 25.5 (1–60) | 0% | ns | [80] |
| Guerrini et al. (2016) | 1 yr: 88.2%; 3 yrs: 71.4%; 5 yrs: 60.6%; 10 yrs: 41.3% | ns | ns | 0% | ns | [39] |
| Gafencu et al. (2017) | ns | ns | ns | 0 | 2.75% | [22] |
| Kim et al. (2017) | 5 yrs: 62.9% | 3 yrs: 50.7% | ns | ns | ns | [23] |
| Shiomi et al. (2017) | 5 yrs: 76% | 5 yrs: 41% | ns | ns | ns | [81] |
| Sun et al. (2017) | 5 yrs: 71.3% | ns | ns | ns | ns | [82] |
| Shiono et al. (2017) | 5 yrs: 70.5% | 5 yrs: 38.2% | ns | 0% | 6.5% | [14] |
| Lodeweges et al. (2017) | 5 yrs: 41% | 1 yr: 56% | ns | ns | ns | [24] |
Survival values expressed as months (range).
ns: Not stated; OS: Overall survival; PFS: Progression-free survival; VATS: Video-assisted thoracic surgery.