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. 2020 May 25;2020:1860637. doi: 10.1155/2020/1860637

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Copyright © 2020 Weidong Gao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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EUP inhibits activation of the NF-κB pathway induced by liver I/R. Protein expression of MyD88 (a), TRAF6 (b), p65 (c), phospho-p65 (d), IKB-α (e), and phospho-IKB-α (f) were detected by Western blot, and the data are expressed as mean ± SD. Compared with the I/R group, the protein expression levels of MyD88, TRAF6, p65, phospho-p65, and phospho-IKB-α were significantly decreased in the EUP high-dose group, and the protein expression of IKB-α was significantly elevated in the EUP high-dose group. The results showed that EUP could significantly inhibit the phosphorylation of IKB-α and p65, thereby reducing the inflammatory response (^★compared with the I/R group, P < 0.05).