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. 2020 May 25;2020:2863236. doi: 10.1155/2020/2863236

Figure 2.

Figure 2

Effects of miR193b transfection on gastric cancer cell lines. (a) MTS assay showing cell viability. miR193b inhibits cell proliferation of SGC-7901, BGC-823, and AGS cells. Cell viability was determined by cell count 72 hours after transfection. (b) No difference in cell cycle progression was detected after transfection with miR193b. (c, d) Transfection with miR193b can induce apoptosis in GC cells (SGC-7901, BGC-823, and AGS) while miR193b inhibitor treatment reduced apoptosis compared to the negative control group. (e) Comet assay confirmed that overexpression of miR193b promotes DNA damage. (f) The protein levels of cleaved-caspase3, bax, and bcl-2 were determined by Western blot analysis after transfection with miR193b or negative-control miRNA. ∗p < 0.05 and ∗∗p < 0.01 were calculated using Student's t-test.