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. 2020 May 25;2020:2863236. doi: 10.1155/2020/2863236

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Copyright © 2020 Ruyue Tian et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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P-Akt is an upstream regulator of miR193b. (a) The expression of miR-193b was negatively correlated with the phosphorylation of Akt in gastric cancer cells. (b) qRT-PCR measurements of miR193b expression in cells transfected with Myr-Akt1 or treated with Akt inhibitor (LY294002). (c, d) Western blot measurements of KRAS protein after treatment with IGF-1 or Myr-Akt1. (e, f) miR193b reduced the inhibitory effect of IGF-1/Myr-Akt1 on apoptosis of SGC-7901 cells. (g, h) Western blot measurement of cleaved-caspase3, bax, and bcl-2 in cells overexpressing miR193b after IGF-1/Myr-Akt1 treatment. ^∗p < 0.05 and ^∗∗p < 0.01 were calculated using Student's t-test.