Figure 2.

Hot plate test: lidocaine intraplantar (4 mg/kg, 0.1 ml/foot) application produced complete anesthesia (left) and considerable plantar damage (right) (CON). Therapy effect: BPC 157 medication (10 μg/kg (Bμ), 10 ng/kg (Bn)) applied immediately after lidocaine (white bars), as an intraplantar , intraperitoneal, or intragastric application in each foot, considerably counteracted local anesthesia and ameliorated posthot plate test-induced plantar presentation (middle). Prophylactic effect: BPC 157 medication (10 μg/kg (Bμ), 10 ng/kg (Bn)) applied intraperitoneally at 5 min before lidocaine (gray bars) considerably counteracted local anesthesia and ameliorated posthot plate test-induced plantar presentation (right). (a) Hot plate test, time with no pain reaction, sec. (b) Hot plate test-induced plantar oedema, scored 0–3; values are presented as mean ± SD and min/med/max. ^∗P < 0.05 at least vs. control.