Figure 8.

Spinal block (function failure and flaccid paralysis): intrathecal anesthesia produced a prolonged hind limbs function failure and long-lasting flaccid paralysis (white bars) which BPC 157 opposed. Prophylactic effect: BPC 157 medication (gray bars) (10 μg/kg (light gray bars), 10 ng/kg (dark gray bars) intraperitoneally) given immediately after lidocaine (a) considerably counteracted lidocaine-induced course. Therapy effect: BPC 157 medication (gray bars) (10 μg/kg (light gray bars), 10 μg/kg (dark gray bars) intraperitoneally) given later, at 10 minutes after lidocaine (b), considerably counteracted lidocaine-induced course. With BPC 157 medication (10 μg/kg, 10 μg/kg intragastrically), an alike counteraction appears as well (data not specifically shown). Intrathecal anesthesia at the L4-L5 level rat spine, scored 0–3. Values are presented as min/med/max. ^∗P < 0.05 at least vs. control.