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. 2020 May 21;106(6):748–763. doi: 10.1016/j.ajhg.2020.04.008

Figure 3.

Figure 3

Motif Enrichment Analysis of EC Regulatory Elements and molQTLs

(A) Discovery of TF binding motifs enriched in all regulatory elements (top), or those specific to IL-1b treatment (bottom). p values for enrichment are compared to random background (top), or untreated (bottom)., Respective densities of these motifs are shown to the right relative to the summit of the ATAC-seq-defined peak.

(B) Y-axes are enrichment of motif mutations in bins of allele-specific ATAC-seq tags on the x-axes for each motif indicated in notx (blue) and IL-1b (red) datasets as normalized to 0.5 (equal tags on ref versus alt). x values of 0 = exclusive openness on ref.; values of 1 = exclusive openness on the alt.

(C) Instances of motif mutations created by alt. or ref. alleles (x axis) show expected effects on ratios of allele-specific accessibility (y axis) for AP-1, ETS, and kB motif mutations in notx (blue) and IL-1b-treated (red) ATAC-seq datasets. p values are from an unpaired two-tailed t test assuming unequal variance.