Figure 5.
Mediation Effect of Obesity in the Causal Link between Inversions and Diabetes and Hypertension
(A) Mediation analysis of obesity in the association between inversion 8p23.1 and diabetes, showing a proportion of the mediation of 38% (p value < 10e−6), which is the Best Bayesian Network when analyzing these three variables. Significant test for the proportion of the median showed a p value < 10−16.
(B) Best Bayesian Network based on AIC obtained after including obesity, hypertension, diabetes, and inversions 8p23.1, 16p11.2, and 11q13.2. Results are obtained from UKB data.