Table 2.
Association between Inversions 8p23.1 and 16p1.2 and Different Obesity-Related Traits in UKB and Replication Datasets
| Disease |
Inversion 8p23.1 (Effect of Risk-Haplotype: N-Allele) |
Inversion 16p11.2 (Effect of Risk-Haplotype: N-Allele) |
||||||
|---|---|---|---|---|---|---|---|---|
|
UKB |
Replication |
UKB |
Replication |
|||||
| OR CI95% | p Value | OR CI95% | p Value | OR CI95% | p Value | OR CI95% | p Value | |
| Obesity | 1.04 (1.03–1.05) | 2.4 × 10−13 | 1.08 (1.04–1.11) | 5.6 × 10−6 | 1.05 (1.04–1.06) | 3.9 × 10−24 | 1.07 (1.03–1.10) | 1.4 × 10−4 |
| Diabetes | 1.04 (1.01–1.06) | 1.1 × 10−3 | 1.08 (1.05–1.11) | 1.1 × 10−8 | 1.02 (0.99–1.04) | 0.1450 | 1.07 (1.04–1.11) | 1.2 × 10−6 |
| Hypertension | 1.04 (1.03–1.05) | 7.0 × 10−16 | 1.03 (1.00–1.05) | 0.0183 | 1.01 (1.00–1.02) | 0.0184 | 1.02 (0.99–1.05) | 0.2127 |
| Asthma | 1.03 (1.01–1.04) | 7.0 × 10−5 | 1.02 (0.90–1.05) | 0.2225 | 1.00 (0.99–1.01) | 0.9529 | 1.00 (0.97–1.04) | 0.8074 |
| Depression | 0.98 (0.97–0.99) | 0.0119 | 1.01 (0.97–1.05) | 0.6630 | 0.98 (0.96–1.00) | 0.0184 | 1.01 (0.98–1.05) | 0.5384 |
| Joint Occurrence of Obesity with: | ||||||||
| Diabetes | 1.08 (1.05–1.11) | 3.1 × 10−7 | 1.17 (1.12–1.22) | 1.4 × 10−13 | 1.06 (1.03–1.08) | 7.5 × 10−5 | 1.13 (1.08–1.17) | 1.2 × 10−8 |
| Hypertension | 1.07 (1.05–1.08) | 1.7 × 10−16 | 1.06 (1.02–1.11) | 6.9 × 10−3 | 1.06 (1.05–1.07) | 2.7 × 10−14 | 1.05 (1.00–1.10) | 0.0357 |
| Asthma | 1.08 (1.06–1.10) | 3.0 × 10−11 | 1.09 (1.02–1.16) | 9.7 × 10−3 | 1.05 (1.03–1.07) | 7.4 × 10−6 | 1.08 (1.01–1.15) | 0.0287 |
| Depression | 1.04 (1.02–1.07) | 1.4 × 10−3 | 1.12 (1.04–1.20) | 3.8 × 10−3 | 1.06 (1.03–1.08) | 1.4 × 10−6 | 1.03 (0.95–1.11) | 0.5241 |
The table shows the odds ratios (OR) and their confidence intervals at 95% (CI95%) for the non-inverted allele and different diseases and the joint co-occurrence with obesity at UKB and replication datasets. The p corresponds to the best genetic model depict in the first column of each inversion.