Table 2.
Proteins that show differences between AD and control groups across independent studies
| Number of articles | Gene (Protein) |
|---|---|
| 18 | APOE (APOE)$ |
| 15 | VGF (VGF) |
| 14 | TTR (TTHY)$ |
| 11 | CHGA (CMGA)$, CST3 (CYTC)$ |
| 10 | SERPINA1 (A1AT)$, APOA1 (APOA1)$ |
| 9 | C4 (CO4)$, CLU (CLUS)$, SPP1 (OSTP)$, PCSK1N (PCSK1N) |
| 8 | C3 (CO3)$ |
| 7 | PTGDS (PTGDS)$, B2M (B2MG), GC (VTDB)$ |
| 6 | ALB (ALBU)$, A2M (A2MG)$, APOH (APOH)$, CHI3L1 (CH3L1), NPTX1 (NPTX1), NPTXR (NPTXR), SCG2 (SCG2), RBP4 (RET4) |
| 5 | TF (TRFE)$, AGT (ANGT)$, FABP (FABPH), GSN (GELS)$, HP (HPT)$, SERPINA3 (AACT)$, CNDP1 (CNDP1)$, CP (CERU)$, CHGB (SCG1)$, ITM2B (ITM2B), SCG3 (SCG3) |
| 4 | A1BG (A1BG)$, FGB (FIBB), PLG (PLMN)$, NRXN1 (NRX1A), MDH1 (MDHC), APOD (APOD)$, CFB (CFAB)$, HPX (HEMO)$, IGFBP2 (IBP2), RETN (RETN), DAG1 (DAG1), APP (A4), FGA (FIBA), SPRC (SPARC), SPON1 (SPON1), GOT1 (AATC), APLP2 (APLP2), SCG5 (7B2), CLSTN1 (CSTN1), MCAM (MUC18), SERPINF1 (PEDF)$ |
| 3 | AMBP (AMBP), ITIH1 (ITIH1), LRG1 (A2GL), MT3 (MT3), NEGR1 (NEGR1), RNASE1 (RNASE1), SORT1 (SORT), APOC1 (APOC1), ALDOA (ALDOA), C2 (CO2), PKM (KPYM), AFM (AFAM), APOA2 (APOA2)$, CLEC3B (TETN), CFD (CFAD), HGF (HGF), PPY (PAHO), PSAP (SAP),VEGF (Q9UNS8), CNTN1 (CNTN1), NCAM1 (NCAM1), SPARCL1 (SPRL1)$, CXCL16 (CXL16), SPOCK1 (TICN1), VEGFA (VEGFA), EFEMP1 (FBLN3)$, BASP1 (BASP1), KNG1 (KNG1)$, NSG1 (NSG1), PRNP (PRIO), SERPINC1 (ANT3)$, SMOC1 (SMOC1), SOD1 (SODC), APLP1 (APLP1) |
| 2 | CTSD (CATD), ACTA2 (ACTA), ATP6AP1 (VAS1), AZGP1 (ZA2G)$, C1QB (C1QB), C5 (CO5), C6 (CO6), ENO2 (ENOG), ENPP2 (ENPP2)$, IGF2 (IGF2), KLK6 (KLK6)$, LCAT (LCAT), LTBP2 (LTBP2), LYNX1 (LYNX1), NFASC (NFASC), NRGN (NEUG), NRXN3 (NRX3B), PAM (AMD), PPIB (PPIB), PTPRD (PTPRD), PTPRN (PTPRN), SEZ6L (SE6L1), TAC1 (TKN1), GAP43 (NEUM), CHL1 (NCHL1)$, ORM1 (A1AG1)$, KRT9 (K1C9), IGFBP7 (IBP7), LDLR (LDLR), MMP10 (MMP10), TNFSF10 (TNF10), ADIPOQ1 (ADIPO), CPE (CBPE), CCL16 (CCL16), CD14 (CD14), CD40 (TNR5), C7 (CO7), C1R (C1R), DCD (DCD), HRG (HRG), IGFBP6 (IBP6), INS (A6XGL2), L1CAM (L1CAM), MMP2 (MMP2), MB (MYG), NBL1 (NBL1), NPDC1 (NPDC1), NRCAM (NRCAM)$, OGN (MIME), PRL (Q5THQ0), SERPINA7 (THBG), SERPINE1 (PAI1), CNTN2 (CNTN2), CD99 (CD99), ITM2C (ITM2C), PENK (PENK), SPOCK2 (TICN2), STT (SMS), TAC (TKNK), ITIH4 (ITIH4), SOD3 (SODE), VTN (VTNC), CADM3 (CADM3), CLSTN3 (CSTN3), COL1A1 (CO1A1), FBLN1 (FBLN1)$, IGSF8 (IGSF8), NCAN (NCAN), PBXIP1 (PBIP1), PGLYRP2 (PGRP2), TGOLN2 (TGON2) |
The number of studies which detected these changes is included. $ proteins which are abundant in CSF of healthy individuals (Schilde et al. 2018)