Fig. 6.

Krill oil inhibited histidine metabolism in pigs. a A diagram showing histidine metabolism pathway. b The normalized transcript abundance of a gene encoding l-histidine decarboxylase (HDC) that was significantly reduced by krill oil (KO) in proximal colon tissue. SC: uninfected pigs fed SO. SI: infected pigs fed SO. KC: uninfected pigs fed KO. KI: infected pigs fed KO. c The important metabolites in distinguishing the supplementation status ranked based on variable importance in projection (VIP) scores using partial least squares—discriminant analysis (PLS-DA) in infected pigs. d The important genera selected by the random forests regression model that were associated with colon luminal histamine levels. % IncMSE = % increase in mean squared error