Table 1.

Krill oil (KO) supplementation increased the metabolites involved in pro-resolving pathways, particularly the biosynthesis of E-series resolvins. Fold change was calculated based on normalized peak intensities in Citrobacter rodentium induced colitis mice (CM) divided by those in healthy control mice (Down dysregulation) or those in KO divided by CM (Up dysregulation). Pathway: A: aspirin triggered resolvin E biosynthesis; B, aspirin-triggered lipoxin biosynthesis; C, lipoxin biosynthesis; and D, leukotriene biosynthesis

Metabolite	Pathway*	Fold change	P value	Dysregulation	m/z	RT
(5S)-HPETE	D*	0.33	0.0004	Down	381.2270	3.974
(15R)-hydroxyeicosapentaenoate	B*, C**	0.36	0.0022	Down	365.2321	4.474
(5S)-HPETE	D*	0.40	0.0024	Down	395.2428	5.266
(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate	A**	0.20	0.0037	Down	347.2217	7.754
15 [epi-] lipoxin A4/B4	B*, C**	0.37	0.0031	Down	411.2375	4.481
18R-hydroxy-eicosapentaenoate	A**, C**, D*	0.34	0.0020	Down	363.2167	4.736
5S hydro(peroxy),18R-hydroxy-eicosapentaenoate	A**	0.25	0.0009	Down	349.2010	5.702
Resolvin E1	A**	0.29	0.0023	Down	409.2217	3.840
15S-hydroxypentaenoate	B**, C***	1.70	0.0406	Up	340.2020	9.158
leukotriene A4	A*, B**, C***	1.68	0.0067	Up	363.2167	5.253
Resolvin E2	A*, B**, C***	1.79	0.0315	Up	315.1957	7.663

m/z mass-to-charge ratio, RT retention time in min

***p < 0.001; **p < 0.01; *p < 0.05.