Table 2.
GRADE Evaluation.
| Certainty Assessment |
No. of Patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Studies | Study Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Intervention | Control | Relative (95% CI) | Absolute (95% CI) | ||
| Mortality | ||||||||||||
| 8 | Randomized trials | Seriousa | Not serious | Not serious | Not serious | None | 93/656 (14.2%) | 125/579 (21.6%) | RR 0.76 (0.62-0.93) | 52 fewer per 1000 (from 82 fewer to 15 fewer) | ⨁⨁⨁◯ MODERATE |
9—critical |
| Recurrence | ||||||||||||
| 3 | Randomized trials | Seriousa | Not serious | Not serious | Not serious | None | 25/367 (6.8%) | 42/294 (14.3%) | RR 0.52 (0.29-0.92) | 69 fewer per 1000 (from 101 fewer to 11 fewer) | ⨁⨁⨁◯ MODERATE |
8—critical |
Abbreviations: GRADE, Grading of Recommendation Assessment, Development, and Evaluation; CI, confidence interval; RR, risk ratio.
a
All studies were judged to include a risk of bias.