Figure 4.

The 24-month treatment regimen course summarized with a comprehensive therapy parameter. For 10 patients of the long-term cohort here is outlined roughly, which interventions they received after surgery (surg) between T0 and T3. The individual time frames of radiation (Rad), endocrine therapy (yellow), chemotherapy (Ctx; red), immunotherapy (orange), and mistletoe (subcutaneous VA (light green), and intravenous VA (dark green) applications are indicated. For Ctx, the summand −3, for immunotherapy −3, for endocrine therapy −1, for subcutaneous VA applications +1, and intravenous VA applications +2 were assigned (for details see Methods section Statistical analysis); and for all patients, their individual therapy sum parameter values (tx) were calculated.