Table 6.

Association Factors for Changes of EORTC QLQ-C30 Fatigue Scores^a,b.

A				B
Demographic Variables	Estimate β	SE	P	Demographic Variables	Estimate β	SE	P
Age	0.052	0.346	.88	Age	0.086	0.346	.803
BMI <25	Reference			BMI <25	Reference
Overweight	5.550	6.257	.377	Overweight	4.470	6.281	.478
Obese	5.089	8.935	.57	Obese	5.765	8.912	.519
Postmenopausal	Reference			Postmenopausal	Reference
Perimenopausal	−15.306	15.992	.341	Perimenopausal	−11.689	16.145	.471
Premenopausal	−9.931	9.511	.299	Premenopausal	−9.612	9.475	.313
UICC stage 0 or I	Reference			UICC stage 0 or I	Reference
UICC stage II or III	−1.828	5.966	.76	UICC stage II or III	−2.355	5.954	.693
Interventions				Interventions
Ctx	15.217	6.212	.016*	Ctx	18.563	6.654	.0063*
				Endocrine therapy	8.508	6.229	.175
C				D
Demographic Variables	Estimate β	SE	P	Demographic Variables	Estimate β	SE	P
Age	0.003	0.339	.994	Age	0.052	0.348	.882
BMI <25	Reference			BMI <25	Reference
Overweight	5.905	6.151	.339	Overweight	5.430	6.416	.399
Obese	5.855	8.792	.507	Obese	5.018	9.010	.579
Postmenopausal	Reference			Postmenopausal	Reference
Perimenopausal	−14.134	15.685	.37	Perimenopausal	−15.545	16.272	.342
Premenopausal	−10.846	9.358	.249	Premenopausal	−9.942	9.557	.301
UICC stage 0 or I	Reference			UICC stage 0 or I	Reference
UICC stage II or III	−2.427	5.853	.679	UICC stage II or III	−1.837	5.995	.76
Interventions				Interventions
Ctx + immune	12.936	4.121	.0022*	Ctx	15.379	6.481	.0195*
Only Ctx: 1; Ctx + immune: 2				VA	−0.563	6.034	.926
E				F
Demographic Variables	Estimate β	SE	P	Demographic Variables	Estimate β	SE	P
Age	0.055	0.348	.875	Age	0.0003	0.34	.999
BMI <25	Reference			BMI <25	Reference
Overweight	5.152	6.370	.421	Overweight	5.235	6.254	.405
Obese	4.870	8.990	.589	Obese	5.539	8.830	.532
Postmenopausal	Reference			Postmenopausal	Reference
Perimenopausal	−16.277	16.262	.319	Perimenopausal	−15.555	15.880	.33
Premenopausal	−9.760	9.561	.31	Premenopausal	−10.640	9.389	.26
UICC stage 0 or I	Reference			UICC stage 0 or I	Reference
UICC stage II or III	−1.823	5.990	.761	UICC stage II or III	−2.396	5.870	.684
Interventions				Interventions
Ctx	16.359	6.931	.020*	Ctx + immuno	14.180	4.559	.0024*
VA sc/iv	−1.679	4.436	.706	VA sc/iv	−2.795	4.325	.52
Only sc VA: 1; iv VA: 2

Abbreviation: EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Health-Related Quality of Life Core Questionnaire; SE, standard error; BMI, body mass index; UICC, Union for International Cancer Control; Ctx, chemotherapy; VA, Viscum album L. therapy; sc, subcutaneous; iv, intravenous.

^aTNM staging according to the (UICC).

^bNegative estimate β values indicate an association with an improvement of fatigue, while positive estimate β values indicate an association with worsening of fatigue. *P < 0.05.