Table 7.

Association Factors for Change of EORTC QLQ-C30 Scores^a.

EORTC	Insomnia		n = 106	Fatigue		n = 105	Physical		n = 106
	Estimate β	SE	P	Estimate β	SE	P	Estimate β	SE	P
Demographic variables
Age	−0.878	0.439	.048*	−0.002	0.334	.994	−0.232	0.206	.262
BMI <25	Reference			Reference			Reference
Overweight	−6.367	8.003	.428	3.394	6.035	.575	−5.266	3.745	.163
Obese	−5.312	11.488	.645	5.845	8.656	.501	−8.603	5.355	.111
Postmenopausal	Reference			Reference			Reference
Perimenopausal	−17.278	20.523	.402	−14.838	15.454	.339	13.092	9.603	.176
Premenopausal	−41.085	12.084	.001*	−10.824	9.256	.243	−4.242	5.654	.455
UICC stage 0 or I	Reference			Reference			Reference
UICC stage II or III	−5.924	7.565	.435	−3.103	5.773	.592	1.263	3.540	.722
Interventions
Therapyb	−5.693	2.128	.0086*	−5.874	1.605	.0004*	2.882	0.996	.0046*

Abbreviation: EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Health-Related Quality of Life Core Questionnaire; SE, standard error; BMI, body mass index; UICC, Union for International Cancer Control.

^aFor insomnia or fatigue, negative estimate β values indicate an association with an improvement of symptoms. For physical functioning, positive β values indicate an association with an improvement.

^bA comprehensive therapy sum parameter as a continuous variable was generated. For all patients, their individual therapy sum parameter values were calculated as illustrated in Figure 4. *P < 0.05.