Figure 4.

Changes in the mechanical allodynia and thermal hyperalgesia by iNOS and nNOS inhibitors. Figure 4(a) and (b) shows the changes in MWT and TWL by iNOS inhibitor 1400 W; Figure 4(c) and (d) shows the changes in MWT and TWL by nNOS inhibitor 7-NI. The values are expressed as Mean ± S.E.M. All rats received a DNP model. The MWT and TWL of rats were measured every Monday for six weeks, beginning from one-week post-STZ injection. H₂S-M: middle concentration of H₂S (20 ppm); 1400 W-L: lower concentration of 1400 W (1 µg); 1400 W-M: middle concentration of 1400 W (5 µg); 1400 W-H: higher concentration of 1400 W (10 µg); 7-NI-L: lower concentration of 7-NI (1 µg); 7-NI-M: middle concentration of 7-NI (10 µg); 7-NI-H: higher concentration of 7-NI (100 µg). MWT: mechanical withdrawal threshold; TWL: thermal withdrawal latency. *P < 0.05 compared to H₂S-M. n = 12 per group. (A color version of this figure is available in the online journal.)