Figure 5.

Changes in the mechanical allodynia and thermal hyperalgesia by sGC and PKG inhibitors. Figure 5(a) and (b) shows the changes in MWT and TWL by sGC inhibitor ODQ; Figure 5(c) and (d) shows the changes in MWT and TWL by PKG inhibitor KT5823. The values are expressed as Mean ± S.E.M. All rats received a DNP model. The MWT and TWL of rats were measured every Monday for six weeks, beginning from one-week post-STZ injection. H₂S-M: middle concentration of H₂S (20 ppm); ODQ-L: lower concentration of ODQ (1 µg); ODQ-M: middle concentration of ODQ (10 µg); ODQ-H: higher concentration of ODQ (20 µg); KT5823-L: lower concentration of KT5823 (100 ng); KT5823-M: middle concentration of KT5823 (500 ng); KT5823-H: higher concentration of KT5823 (1 µg). MWT: mechanical withdrawal threshold; TWL: thermal withdrawal latency. ^*P < 0.05 compared to H₂S-M. n = 12 per group. (A color version of this figure is available in the online journal.)