Figure 7.

Changes in the mechanical allodynia and thermal hyperalgesia by opioid receptor antagonists. Figure 7(a) and (b) shows the changes in MWT and TWL by κ-opioid receptor antagonist Nor-BNI; Figure 7(c) and (d) shows the changes in MWT and TWL by μ-opioid receptor CTOP; Figure 7(e) and (f) shows the changes in MWT and TWL by δ-opioid receptor antagonist naltrindole. The values are expressed as Mean ± S.E.M. The MWT and TWL of rats were measured every Monday for six weeks, beginning from one-week post-STZ injection. H₂S-M: middle concentration of H₂S (20 ppm); Nor-BNI-L: 10 µg Nor-BNI; Nor-BNI-M: 20 µg Nor-BNI-M; Nor-BNI-H: 40 µg Nor-BNI; CTOP-L: 1 µg CTOP-L; CTOP-M:10 µg CTOP; CTOP-H: 20 µg CTOP; Naltrindole-L: 5 µg Naltrindole; Naltrindole-M: 10 µg Naltrindole; Naltrindole-H: 20 µg Naltrindole. MWT: mechanical withdrawal threshold; TWL: thermal withdrawal latency. ^*P < 0.05 compared to H₂S-M. n = 12 per group. (A color version of this figure is available in the online journal.)